JAPANESE ZINC SMELTER
TOKYO - Japan's Hachinohe zinc smelter has halted operation after a severe earthquake hit northern Japan on Wednesday night, and high-purity 99.99 percent grade zinc production will
not resume for about two months, a smelter official said Thursday.
Manao Moriyama, deputy chief at the 101,000-metric-ton-a-year smelter, said production of regular-purity 98.5 percent zinc is expected to be restored shortly.
But damage to a refining line is more severe, and it will take nearly two months before production of 99.99 percent grade zinc resumes, Mr. Moriyama said.
IN UPJOHN DRUG TEST
KALAMAZOO, Mich. - Upjohn Co. has suspended enrollment in a clinical trial of tirilazad mesylate for treating severe and moderate head injuries because of an unexpected and unexplained difference in mortality rates.
The pharmaceutical firm, based here, said enrollment in the approximately 1,200-patient North American trial was suspended at the recommendation of an independent safety committee because of a higher rate of mortality in patients treated with tirilazad in doses of 10 milligrams per kilogram a day for five days compared with a placebo group.
Upjohn said mortality in both groups was primarily associated with swelling of the brain, the most common cause of death in patients with severe and moderate head injuries.
Upjohn said the finding was unexpected because an independent safety committee
for a similar European study reported no safety concerns with tirilazad.